増殖因子および培養細胞を用いた唾液腺の再生

  • 各務 秀明
    名古屋大学医学部組織工学 (日立メディコ) 寄附講座
  • 杉戸 孝行
    名古屋大学医学部組織工学 (日立メディコ) 寄附講座 名古屋大学大学院医学系研究科頭頚部感覚器外科学講座顎顔面外科学
  • 上田 実
    名古屋大学大学院医学系研究科頭頚部感覚器外科学講座顎顔面外科学 東京大学医科学研究所幹細胞組織医工学 (歯胚再生学) 寄付研究部門

書誌事項

タイトル別名
  • Regeneration of salivary gland by use of growth factors and cultured salivary gland cells
  • ゾウショク インシ オヨビ バイヨウ サイボウ オ モチイタ ダエキセン ノ サイセイ

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抄録

Salivary gland dysfunction is not only a common inter estin the field of oral medicine but also an important clinical consideration for general dentistry. Hyposaliva tionaffects various oral conditions including dental caries, denture problems and oral discomfort. Medications such as pirocarpine and sevemelin hydrochloride can induce salivation from the residual tissue and temporar ilyrelieve patients' symptoms. However, there is no treatment to repair the damaged salivary gland. Recently, new technology-based treatments such as tissue engineering or (stem) cell therapy have been reported by use of autologous or allogenic cells in several fields. These technologies utilize cells to rebuild, restore or regenerate damaged tissue and have been successfully applied for patients with severe burns, cartilage defects and cardiovascular tissue replacement. Furthermore, growth factors have been used in clinics to induce tis sueregeneration in cases of delayed wound healing or to accelerate organ regeneration. Unlike the medications used for dry mouth patients, these new technologies have the potential to regenerate the damaged organ or tissue itself. In terms of the salivary gland, there is no treatment to repair an atrophic or damaged gland at present. However, there have been an increasing number of studies which may lead to such new treatments. In this review, the possibility of cell therapy and growth factor therapy for the salivary gland are discussed.

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