ラット抜歯窩治癒過程におけるアテロコラーゲンとアテロコラーゲンを担体とした多血小板血漿の効果について

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  • The effect of atelocollagen and platelet-rich plasma with atelocollagen on the healing process of tooth extraction sockets in rats
  • ラット バッシカ チユ カテイ ニ オケル アテロコラーゲン ト アテロコラーゲン オ タンタイ ト シタ タケッショウバン ケッショウ ノ コウカ ニ ツイテ

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Platelet-rich plasma (PRP) contains many growth factors released from concentrated platelets, and is expected to promote tissue regeneration. The present study investigated the effect of PRP on the healing process of the tooth extraction socket in rats through the histological observation of an activated PRP-soaked atelocollagen group (aPRP group), an atelocollagen group (AC group), and an extraction only group (control group).<BR>The PRP of rats was prepared by using the double spin method; 1st spin, 200×g for 10 minutes followed by 2nd spin, 300×g for 10 minutes, yielding a platelet concentration of 6.24 times. It was confirmed by ELISA that TGF-β1 and PDGF-BB were released abundantly by activation of this PRP.<BR>In all three groups, new bone was started forming from the mesial and distal socket wall in the bottom of the socket. In the control group, new bone was formed adding to the socket wall, but in the AC group and the aPRP group, new bone was formed along the atelocollagen.<BR>Throughout the test period, absorption of atelocollagen and osteogenesis was more conspicuous in the aPRP group than in the AC group. On day 21, in the aPRP group, atelocollagen remained in the tooth extraction socket, but new bone was formed at the top of the socket at the same level as in the control group.<BR>It is suggested that atelocollagen inserted in the extraction socket of rats delayed new bone formation, and activated PRP promotes the delayed formation of new bone to an extent similar to that as if nothing was inserted.

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