Sister chromatid exchange of golden hamster. On the lymphocytes in experimental malignant tumor.
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- SAKAI Hiroya
- Second Department of Oral and Maxillofacial Surgery, School of Dentistry, Niigata University Department of Oral Pathology, School of Dentistry, Niigata University
Bibliographic Information
- Other Title
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- ゴールデンハムスターにおける姉妹染色分体交換に関する研究 実験的担癌体末梢血リンパ球による検討
- On the lymphocytes in experimental malignant tumor
- 実験的担癌体末梢血リンパ球による検討
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Abstract
The incidence of spontaneous and mitomycin C (MMC)-induced sister chromatid exchange (SCE) was investigated in peripheral lymphocytes of 7 male golden hamsters bearing transplanted squamous cell carcinoma in the cheek pouch and 7 normal controls. The results are summarized as follows.<BR>1. Both tumor bearing and control groups were sensitive to SCE induction by MMC.<BR>2. The mean incidence of spontaneous SCE in the tumor bearing group (7.65±0.78) was significantly higher (Wilcoxon, P<0.005) than that in the control group (5.72±0.41).<BR>3. The mean incidence of SCE induction by 5 ng/ml of MMC was 16.0 ±1.73 in the tumor bearing group and 12.29±1.38 in the controls. The corresponding values at a dose of 10 ng/ml of MMC were 20.39±1.38 and 17.36±1.14, respectively. The incidence of SCE in the tumor bearing group was significantly higher (P<0.005) than that in the control group at either dose of MMC.<BR>The results suggest that peripheral lymphocytes of the golden hamster are useful for investigating SCE, and that SCE could be used as a preclinical parameter to predict the presence of malignant tumor.
Journal
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- Journal of The Japanese Stomatological Society
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Journal of The Japanese Stomatological Society 39 (2), 450-458, 1990
Japanese Stomatological Society
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Details 詳細情報について
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- CRID
- 1390001206437512960
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- NII Article ID
- 130004335240
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- ISSN
- 21850461
- 00290297
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- Text Lang
- ja
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- Data Source
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- JaLC
- CiNii Articles
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- Abstract License Flag
- Disallowed