Histochemical Studies upon the Experimental Diabetic and Sulfonylurea Administered Rabbits

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  • 実験的糖尿家兎及びスルファニール尿素剤投与家兎に於ける糖原及び脂肪の組織化学的検討
  • ジッケンテキ トウ ニョウ カト オヨビ スルファニール ニョウソザイ トウヨ カト ニ オケル トウ ゲン オヨビ シボウ ノ ソシキ カガクテキ ケントウ
  • 特にスルファニール尿素剤の作用機序に関連して

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Glycogen and fat in main organs (liver, heart and kidney) of the experimental (alloxan, dithizone and oxine) diabetic and sulfonylurea administered rabbits are histochemically investigated. Demonstration of glycogen is performed by PAS staining method and fat is stained by Sudan black B. A) Experimental diabetic rabbits ;<BR>1) In the hypoglycemic stadium, i.e. 5-10 hours after injection of experimental diabetic agents, liver glycogen disappears at the periphery of liver acini.<BR>2) In the initial period of the secondary hyperglycemic stadium (2-7 days after injection), decrease or disappearance of the liver glycogen are observed. Sometimes lipoid substances in the blood vessels of the liver and kidney are recognized in this period.<BR>3) Glycogen in heart muscles shows increasing tendency throughout all stadiums in almost cases.<BR>4) Glycogen degeneration at the epitherial cells of urinary tubules in the kidney and fat deposition in the liver and kidney are observed in the typical alloxanized rabbit inwhich hyperglycemia has continued several months.<BR>B) Sulfonylurea administered rabbits ;<BR>Liver glycogen decrease or disappear from the liver and blood sugar level increase about 25% higher than normal in the period of 15-60 minutes after oral administration of sulfonylurea. After then liver glycogen begin to increase and blood sugar level begin to decrease with the lapse of time, and after three hours liver glycogen reaches to the normal content, but hypoglycemia continue still more several hours.

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