新生児の尿中に排泄される3β-hydroxy-Δ<SUP>5</SUP>-steroid並びにACTH負荷によるその変動

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タイトル別名
  • Urinary Excretion of 3β-hydroxy-Δ<SUP>5</SUP>-steroids in the Newborn Infant and the effect of ACTH Administration
  • 新生児の尿中に排泄される3β-hydroxy-Δ5-steroid並びにACTH負荷によるその変動
  • シンセイジ ノ ニョウチュウ ニ ハイセツサレル 3ベータ hydroxy デ

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The urinary 3β-hydroxy-Δ5-steroids excreted during the period of the first week by newborn infants were analyzed by means of gas chromatography and gas chromatography-mass spectrometry to study the changes in the amount of these steroids. The changes in the amount of each steroid after the administration of ACTH were also studied. The results are summarized as follows : <BR>1) Seven kinds of 3β-hydroxy-Δ5-steroids were identified in the urine of the newborn infants. 17a, 21-dihydroxypregnenolone was newly identified.<BR>2) The daily changes in the amount of each of these steroids differed. Generally, the amount of the C-19 steroids increased day by day and that of the C-21 steroids decreased during the period of our observation.<BR>3) After the administration of ACTH, the amount of these urinary steroids excreted increased at nearly the same rate.

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