Clinical Studies on Radioimmunoassay for Human Thyrotropin in Patients with Thyroid Disorders

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  • 各種甲状腺疾患におけるHTSH値
  • カクシュ コウジョウセン シッカン ニ オケル HTSHチ

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Serum thyrotropin (TSH) values in normal adults and patients with thyroid disorders were estimated by radioimmunoassay with the double antibody technique, using HTSH Radioimmunoassay kit (supplied from Daiichi Radioisotope Laboratories, Ltd.)<BR>The values in 30 normal adults ranged from undetectable (<2 μUfml) to 7.8, μU/ ml, and 10 of them were undetectable.<BR>In cases with untreated thyroid disorders, TSH values in 25 patients with Graves' disease ranged from undetectable (18 cases, 72%) to 4.4, 2U/ml; in 14 patients with hypothyroidism due to chronic thyroiditis, from 105 to 260 μU/ml; in 15 euthyroid with chronic thyroiditis, from undetectable (3 cases, 20%) to 105, μU/ml; in 14 with simple goiter, from undetectable (7 cases, 50%) to 44 μU/ml; in 37 with follicular adenoma, from undetectable (10 cases, 27%) to 10.3 μU/ml; and in 11 with thyroid carcinoma, from unde-tectable (4 cases, 36%) to 7.3, μU/ml. The patients with Graves' disease had significantly lower TSH levels than the normal adults and other patients with thyroid disorders (p< 0.05).<BR>Serum TSH values were estimated in the patients with Graves' disease during tithyroid drug therapy who were classified as hyperthyroid, euthyroid and hypothyroid. The TSH values in 71 hyperthyroid patients during antithyroid drug therapy, were distributed the same as untreated Graves' disease (p<0.05). But the TSH values in 66 euthyroid patients ranged from undetectable (26 cases, 39%) to 175 pU/ml, and in 6 hypothyroid, from 5.2 to 59 μU/ml.<BR>In the patients treated with subtotal thyroidectomy for Graves' disease, the TSH levels changed as follows : in 15 cases continued hyperthyroid within 1 month after operation, were distributed in the same way as untreated cases (p<0.05); in 44 cases continued euthyroid within 1 month after operation ranged from undetectable (21 cases, 48%) to 160 μU/ml; in 37 euthyroid continued over 6 months, from undetectable (5 cases, 14%) to 180 μU ml ; in 29 patients developed hypothyroid within 6 months after operation, from undetectable to 340 μU/ml, and 14 of them were within normal range (<10 μU/ml). Adn of 7 hypothyroid over 6 months after operation, from 81 to 170 μU/ml.<BR>In 8 euthyroid patients treated with radioiodine for Graves' disease more than 12 months previously, 6 of them had undetectable TSH values.<BR>During triiodothyronine or desiccated thyroid therapy for chronic thyroiditis, serum TSH values in 43 euthyroid patients ranged from undetectable to 450 μU/ml, and in 14 hypothyroid ranged from undetectable to 152 μU/ml.

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