Slowly progressive type 1 diabetes mellitus whose anti-GAD antibody showed positive conversion after 9 years interval from the onset of the disease.

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  • Misaki Asako
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Seino Hiroaki
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Yamaguchi Hiyoshi
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Sakata Yoshiyuki
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Kitagawa Masayuki
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Yamazaki Toshirou
    Department of Internal Medicine in Diabetic Center, Ohta Nishinouchi Hospital
  • Muto Gen
    Department of Internal Medicine, Ohta Memorial Hospital
  • Kikuchi Hiroaki
    Department of Internal Medicine, Ohta Memorial Hospital
  • Abe Ryuzo
    Department of Internal Medicine, Ohta Memorial Hospital

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  • 糖尿病発症９年後にＧＡＤ抗体が陰性から陽性になったＳｌｏｗｌｙ　ｐｒｏｇｒｅｓｓｉｖｅ　１型糖尿病の１例
  • コンゲツ ノ ショウレイ トウニョウビョウ ハッショウ 9ネンゴ ニ GAD コウタイ ガ インセイ カラ ヨウセイ ニ ナッタ Slowly progressive 1ガタ トウニョウビョウ ノ 1レイ

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Abstract

症例は72歳,女性.近医より高血糖を指摘され,受診.初回入院時から尿中CPRが低値であった事と臨床経過より, Slowly progressivel型糖尿病(SP1型糖尿病)を疑い, GAD (Glutamic Acid Decarboxylase)抗体の測定をしたが陰性であった.以後経時的にGAD抗体の測定を行っていたが,発症9年目の平成12年入院時に初めてGAD抗体が陽性となった.本症例はGAD抗体が陰性から陽性化したSP1型糖尿病で,興味深い症例と思われた.

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