ヌードマウスによる?EＣｏｒｙｎｅｂａｃｔｅｒｉｕｍ　ａｎａｅｒｏｂｉｕｍ?Fの抗しゅよう機序に関する研究

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  • Studies on the Anti-tumor Mechanism of <i>Corynebacterium anaerobium</i> with Nude Mice
  • ヌードマウス ニヨル Corynebacterium anaerobium ノ

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The present study was performed to elucidate the anti-tumor mechanism of Corynebacterium anaerobium (CA) against Ehrlich ascites tumor by using athymic nude mice (nu/nu) and hetero (nu/+) mice of the BALB/c strain.<br>1) The anti-tumor effect of CA on both nu/nu and nu/+ groups injected intraperitoneally with a mixture of tumor cells and CA was dose dependent. The most effective dose was 250μg per mouse. The overdose administration was much less effective or ineffective.<br>2) Treatment with carrageenan, which preferentially suppresses the macrophage function, decreased the anti-tumor effect of CA on both groups.<br>3) A remarkable enhancement was demonstrated in the anti-tumor effect of CA on the nu/nu group to which had been transferred the thymic cells of the nu/+ group.<br>4) No significant enhancement was shown in the anti-tumor effect of CA on the nu/nu group with CA-sensitized splenic cells transferred from the nu/+ group exhibiting delayedtype hypersensitivity to CA.<br>5) The nu/+ group, as well as the nu/nu group, to which had been transferred thymic cells, the tumor of which had been completely suppressed by CA, was highly resistant to rechallenge with the tumor cells, presenting a complete rejection.<br>6) Non-adherent cells derived from the spleen and lymph node of the nu/+ group being resistant to rechallenge with the tumor cells, as well as peritoneal macrophages derived from the CA-treated nu/nu group, exerted a strong cytotoxicity on the tumor cells in vitro.<br>From the findings mentioned above, it was concluded that the anti-tumor activity of CA against Ehrlich ascites tumor was effectuated by CA-activated macrophages and cell-mediated immunity to tumor induced by administration with CA and the tumor cells. Another possible anti-tumor mechanism due to the bystander effect of delayed-type hypersensitivity to CA could not be ascertained.

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