クマリン系殺そ剤Warfarinによる凝血障害に関する二,三の知見

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  • 草野 忠治
    東京教育大学農学部応用動物学研究室 鳥取大学農学部応用昆虫学研究室

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タイトル別名
  • Notes on the Coagulation Defect in Mice Poisoned by Coumarin Rodenticides
  • クマリンケイ サッソザイ Warfarin ニ ヨル ギョウケツ ショウガイ ニ カンスル ニ , サン ノ チケン

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The influences of the concentrations of tissue thromboplastin, CaCl2 and the stable factor (SF) on the prothrombin time (PT), the plasma thromboplastin time and fibrin quantity in normal plasma, diluted normal plasma (with saline) and warfarin-poisoned plasma or blood have been examined, and the following results were obtained.<br>1. The concentration of thromboplastin necessary to obtain the minimum value of the PT was 5% in both normal and 40% plasma, and 0.5% in 20% plasma, 10% plasma and warfarin plasma. When the PT was measured by thromboplastin+CaCl2+test plasma, the suitable concentration of thromboplastin was 10% in both normal and 10% plasma, and 5% in warfarin plasma.<br>The concentration of CaCl2 necessary to obtain the minimum value of the PT was 1/40∼1/400M in 40% plasma, 1/40∼1/200M in 20% plasma and 1/40M in 10% plasma. When the PT was measured by thromboplastin+CaCl2+SF+test plasma, the suitable concentration of CaCl2 was 1/40∼1/100M in normal plasma, 1/100M in 10% plasma, and 1/40M in warfarin plasma.<br>2. The concentration of thromboplastin necessary to obtain the minimum value of the plasma thromboplastin time, as measured with thromboplastin+SF+test plasma, was 10% in both normal and warfarin plasma showing the prolonged PT, and 5% in both 10% plasma and warfarin plasma showing the slightly prolonged PT.<br>3. When the PT was measured with the added SF, the plasma thromboplastin time in normal plasma, 10% plasma, warfarin plasma and the PT in warfarin plasma was prolonged progressively according to the dilution of the SF.<br>4. When the concentration of either thromboplastin or CaCl2 was changed keeping the concentration of either CaCl2 or thromboplastin constant, the PT in warfarin plasma was affected more significantly than those in both normal and diluted plasma by the concentration of CaCl2 or thromboplastin.<br>5. Fibrin quantities in normal, diluted and warfarin plasma were affected more significantly by the concentration of CaCl2 than by that of thromboplastin.<br>6. The PT of normal plasma was markedly prolonged by high dose of warfarin in vitro. It was found that this is caused by the inhibition of fibrinogen conversion.

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