マイコプラズマに対するｐｅｒｏｘｉｄａｓｅの増殖抑制作用

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  • Inhibitory effects of peroxidase on the growth of mycoplasmas.
  • マイコプラズマ ニ タイスル peroxidase ノ ゾウショク ヨクセイ

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The inhibitory effects of peroxidase and catalase on the growth of mycoplasmas were investigated. The addition of peroxidase or catalase to liquid medium inhibited the growth of M. pneumoniae, which produces hydrogen peroxide, but not the growth of an H2O2-non producing strain, M. salivarium. Heated peroxidase (at 100C for 15min) and catalase (at 100C for 10min) abolished their inhibitory effects on the growth of mycoplasmas. In the next experiment, M. pneumoniae and M. salivarium were incubated in acetate buffer (pH 5.0) in the presence of hydrogen peroxide and peroxidase at 37C for 60min, and then in fresh PPLO broth at 37C. The CFUs of M. pneumoniae were reduced by 83% in 5 days and those of M. salivarium by 99% in 2 days of cultivation, as compared with control. These results suggest that the peroxidase-H2O2-halide system might be responsible for a part of the defense mechanisms against mycoplasmal infection.

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