Attenuation of Habu-Snake (Trimeresurus flavoviridis) Venom Treatment with Alcohol and Its Effect as Immunizing Antigen

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  • ハブ蛇毒のアルコール処理による弱毒化とその免疫原性について
  • バブ ダドク ノ アルコール ショリ ニ ヨル ジャク ドクカ ト ソノ メンエキ ゲンセイ ニ ツイテ 1 アルコール ショリ バブ ドク ノ ドクセイ オヨビ マウス ニ オケル メンエキ ジッケン
  • 第1報 アルコール処理ハブ毒の毒性およびマウスにおける免疫実験

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Exposure of Habu-snake venom solution to heat at 56°C for 30 minutes causes protein precipitation, which is almost non-toxic. The toxicity of centrifuged supernatant is slightly weakened.<br>When 70% alcohol is added to this supernatants, minute substances which are insoluble in water are precipitated, and the toxicity of the precipitate is remarkably attenuated.<br>By the addition of 0.1%-1% formalin (or Aluminum Potassium Sulfate) to the precipitate, the attenuation of the toxicity tends to increase, and the amount of its protein content is less than 1/2 of that in the non-heated solution. Immunizing effect of formalin-added, alcohol-treated antigen proves effective enough to act as a satisfactory immunogen against the toxicity of Habu-venom-hemorrhagic necrotic damagea t the site.<br>In order to produce antibody in man throng preventive injection against Habu bite, the formalin added, alcohol-treated antigen might be applicable without accompanying any serious by-effects.

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