Studied on the Habu Snake (<i>Trimeresurus flavoviridis</i>) Venom Toxoid

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  • SAWAI Yoshio
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • KAWAMURA Yoshiharu
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • MAKINO Masaaki
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • FUKUYAMA Tamio
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • SHIMIZU Toshio
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • LIN YI HEI
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • KURIBAYASHI Hisanosuke
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • ISHII Takuya
    Laboratory of Biological Products, Institute for Infectious Diseases, The University of Tokyo
  • OKONOGI Takashi
    Department of Pathology, School of Medicine, Gunma University

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Other Title
  • ハブ蛇毒トキソイドの基礎的研究
  • ハブ ダドク トキソイド ノ キソテキ ケンキュウ 1 トキソイド ノ メンエキ ゲンセイ ニ ツイテ
  • 1. トキソイドの免疫原性について

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Description

Mice and rabbits were immunized with Habu Snake Venom treated with equal amount of Freund's incomplete adjuvant, and Cocarboxylase or Dihydrothioctic acid (DHTA). After four weeks, 3 or 5 booster injections of untreated or DHTA treated venom were given weekly. And then, the neutralizing effects of the sera of the animals were tested. They were also challenged intramuscularly into the legs with the venom.<br>It was elucidated that those immunized animals were protected from local hemorrhagic and necrotic action and lethal effect of venom in considerable degree although the protective potency of the sera of the animals was lower than that of antivenin used for treatment of snake bite in man. As it was also confirmed that no side reaction was seen by the injection of DHTA treated venom, an active immunization of men was tried, injecting 5mg of DHTA treated venom divided into two at the interval of two weeks. The immunizing potency of the sera of vaccinated persons was almost the same as that of the animals. Thus, it was suggested that DHTA inactivated toxoid of habu venom was proved to be useful for prophylaxis against the legion caused by Habu snake bite.

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