Regulation of determination of bacterial shape

DOI Web Site PubMed 57 References Open Access
  • SHIOMI Daisuke
    Department of Life Science, College of Science, Rikkyo University

Bibliographic Information

Other Title
  • 細菌形態形成制御機構に関する研究
  • 平成26年黒屋奨学賞受賞論文 細菌形態形成制御機構に関する研究
  • ヘイセイ 26ネン コクヤ ショウガクショウ ジュショウ ロンブン サイキン ケイタイ ケイセイ セイギョ キコウ ニ カンスル ケンキュウ

Search this article

Abstract

Bacteria show various cell shape such as round, rod, helical, and so on. However, each bacterium has its own shape and their length and width are kept in a narrow range in a population. Abnormal cell shape often results in death of the cells. Therefore, it is important to maintain their shape. Rod-shaped bacterium Escherichia coli needs to regulate cell polarity, length and width in order to form rod shape. Bacterial shape is genetically regulated. Especially, MreB, a bacterial actin, and its interacting proteins are involved in the regulation. We have identified rodZ as a novel cell shape determinant and have been analyzing RodZ protein in the past few years. The rodZ mutant is round. We isolated suppressor mutants of the rodZ mutant. The shape of the suppressors was rod shape. By analyzing the rodZ mutant and the suppressors, we concluded that RodZ helps assembly of MreB filaments. MreB plays roles in regulation of cell polarity, length, and width, whereas RodZ is involved in regulation of length and width. In this review, I summarize our research and research from other groups on bacterial cell shape.

Journal

References(57)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top