Quantitative Detections of Hydration and Biscoelastisity of Biomolecules on a QCM
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- OKAHATA Yoshio
- Frontier Collaborative Research Center, Tokyo Institute of Technology
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- FURUSAWA Hiroyuki
- Frontier Collaborative Research Center, Tokyo Institute of Technology
Bibliographic Information
- Other Title
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- ～知っておきたい新計測法～９）水晶発振子を用いた生体分子の水和と粘弾性の定量化
- シッテオキタイ シンケイソクホウ 9 スイショウ ハッシンシ オ モチイタ セイタイ ブンシ ノ スイワ ト ネンダンセイ ノ テイリョウカ
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Abstract
A 27 MHz piezoelectric crystal was connected with a network analyzer. Both a frequency shift (ΔF) and energy dissipation change (ΔD) were observed when biomolecules were immobilized on a piezoelectric plate. Linear biomolecules such as DNA strands showed a large energy dissipation due to their flexible structures and the amount of hydrated water. On the contrary, globular proteins showed a small energy dissipation, which means proteins are relatively rigid. The combination of a piezoelectric crystal and a network analyzer will provide a powerful tool to analyze the hydration and viscoelasticity of biomolecules.
Journal
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- Hyomen Kagaku
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Hyomen Kagaku 28 (10), 606-609, 2007
The Surface Science Society of Japan
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Details 詳細情報について
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- CRID
- 1390001206457175296
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- NII Article ID
- 130004486364
- 10019835694
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- NII Book ID
- AN00334149
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- ISSN
- 18814743
- 03885321
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- NDL BIB ID
- 8971079
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed