スナネズミ線条体細胞外アミノ酸濃度に及ぼすヒスタミン関連薬物の影響:H1およびH2作用の脳虚血による変化

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タイトル別名
  • Histaminergic regulation of transmitter amino acids in the striatum of mongolian gerbils: changes in H1-and H2-actions in cerebral ischemia.

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抄録

The role of histaminergic system on the changes in extracellular amino acids in normal and ischemic conditions was examined by the microdialysis-HPLC procedure. The extracellular concentration of glutamate was reduced by histamine perfusion to 36% in normal condition. This action was antagonized by mepyramine, an H1-antagonist. A further increase in this amino acid was observed after administration of high doses of mepyramine. The forebrain ischemia produced marked increase in the extracellular amino acids. The perfusion of histamine resulted in reduction of the rise in amino acids to about 50%. These effects of histamine were completely antagonized by mepyramine or cimetidine. In the ischemic conditions, cimetidine produced a greater increase in amino acids than in the control animals. These findings suggests that transmitter amino acids were regulated through H1-receptors in normal conditions, but in their rise induced by ischemia were regulated mainly by H2- receptors.

収録刊行物

  • 蘇生

    蘇生 14 (3), 95-101, 1996

    日本蘇生学会

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