甲状腺ホルモンによる血中インスリン様成長因子結合タンパク質(IGFBP),および各組織のIGFBP-2mRNA発現の変化

DOI 日本農学文献記事索引 Web Site Web Site 被引用文献1件 参考文献27件

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  • Effects of Thyroid Hormone on Serum Insulin-Like Growth Factor Binding Proteins(IGFBPs) and IGFBP-2 mRNA Expression in Chickens.

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We examined serum IGF binding proteins (IGFBPs) and tissue (liver, kidney and brain) IGFBP-2 mRNA in 5-weeks-old cockerels with different thyroidal status to elucidate a possible role of thyroid hormone on IGFBPs in the chicken. Assay for serum IGFBPs by Western ligand blot detected three IGFBPs having molecular masses of 30, 36 and 41 kDa. The 125I-IGF-I bindings to these IGFBPs were significantly decreased in propylthiouracil (PTU) induced hypothyroid cockerels, and restored to euthyroid control levels by thyroxine (T4) supplement. T4 supplement to euthyroid birds had no significant influence on 125I-IGF-I binding to IGFBPs. The expression of IGFBP-2 mRNA in the liver was significantly reduced in hypothyroidism and restored to normal level by T4 replacement, whereas T4, injected to intact birds, failed to affect hepatic IGFBP-2 mRNA expression. In contrast, the expression of IGFBP-2 mRNA in the kidney was increased in hypothyroid birds and decreased both in T4-treated intact and hypothyroid birds. In the brain, IGFBP-2 mRNA level was not influenced by the changes in thyroidal status. IGFBP-2 mRNA was detected in all tissues examined, with varying degree. The expression was higher in the testis, gizzard, brain, eye and bursa of fabricius, followed by kidney and digestive organs. In the liver, the expression was very low compared with other tissues.

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