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- 齋藤 繁
- 群馬大学医学部麻酔・蘇生学教室
書誌事項
- タイトル別名
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- Effects of lipid mediator, lysophosphatidic acid, on regenerating chick neurons
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The leading edge of growing and regenerating neuron, nerve growth cone, plays important roles in the regenerating process after neuronal injury. The nerve growth cones collapse when they encounter repulsive factors expressed in the surrounding tissues. Lysophosphatidic acid (LPA) is rapidly generated by activated platelets or by cells after tissue damage, and serves as an intercellular messenger. This lipid mediator caused growth cone collapse in primary cultured chick neurons. This action was dose dependent and the potency was almost identical in three different neuron types: dorsal root ganglion neurons, retinal neurons, and sympathetic ganglion cells. Fifty % of growth cones were collapsed by 10-6 M LPA. The growth cone collapse started within 2 min after LPA exposure and no homologous desensitization was observed. However, this action was reversible and not toxic to the neurons. This result implied that LPA acts as an inhibitory factor of neurite growth after nerve injury in vivo. LPA antagonists seem to be promising as promoting substances of nerve regeneration.
収録刊行物
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- 蘇生
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蘇生 19 (1), 16-22, 2000
日本蘇生学会
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詳細情報 詳細情報について
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- CRID
- 1390001206458998656
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- NII論文ID
- 10009651832
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- NII書誌ID
- AN10043787
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- ISSN
- 1884748X
- 02884348
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可