Characterization of Morphological, Biochemical and Electrocardiological Assessments in Young Cardiomyopathic Hamsters.

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  • 若齢期心筋症ハムスターの形態学的，血液生化学的および心電図学的特徴
  • ジャクレイキ シンキンショウ ハムスター ノ ケイタイガクテキ ケツエキ セイ

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The purpose of this study was to clarify the morphologic, biochemical and electrocardiographical character of young cardiomyopathic hamsters (BI014.6) compared with age-matched healthy hamsters (FIB). In the present study we report following ; (1) The relative weights of the heart and kidney were significantly increased in the cardiomyopathic hamsters compared with the healthy hamsters ; (2) Plasma levels of CPK, GOT, and GPT were significantly higher in the cardiomyopathic hamsters than in the healthy hamsters ; (3) There were no differences in ECG between the cardiomyopathic and healthy hamsters and also arrhythmias at the age of 2.5 months. The intervals of R-R and PQ were significantly shorter in the cardiomyopathic hamsters but the QT interval was significantly longer than in the healthy hamsters. These morphologic aspects and biochemical profiles indicated that the young cardiomyopathic hamsters exhibited a cardiac hypertrophy and disturbance in the heart muscle. However, from the electrophysiological viewpoint, it is probable that the cardiomyopathic hamsters have still managed to be normal at the age.

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