A Guide-Controlled Bead Method for Coronary Occlusion and Reperfusion of Myocardial Ischemia-Infarction Model in the Rabbit

DOI Web Site 11 References
  • MOROHOSHI Yasuo
    Department of Laboratory Animal Science, Kitasato University School of Medicine
  • NAKAYAMA Shigenobu
    Laboratory Animal Facilities, Kitasato University School of Medicine
  • KANAI Takao
    Institute of Laboratory Animals, Tokyo Women's Medical University
  • IKEDA Tadao
    Department of Biology, Nihon University School of Medicine
  • IKEDA Noriaki
    Department of Medical Infomatics, Kitasato University School of Allied Health Science
  • MIYAHARA Hideo
    Department of Medical Infomatics, Kitasato University School of Allied Health Science

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Other Title
  • 実兎を用いた心筋虚血・梗塞モデルのためのビーズ閉塞・再灌流法について
  • ジツ ト オ モチイタ シンキンキョケツ コウソク モデル ノ タメ ノ ビーズ ヘイソク サイカンリュウホウ ニ ツイテ

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In order to investigate ECG changes during myocardial infarction and post-ischemic reperfusion, we need animal model that allows us to establish coronary occlusion with selected vessels, set occlusion time and manipulate the degree of myocardial injury and infarct size. In our study, we made Amplatz-type cardiac catheter for rabbits to develop non-invasive procedure. A stainless bead is attached at the tip of guide wire which was placed in the right or left coronary artery to produce occlusion and procedure for reperfusion was investigated. ECGs were recorded during occlusion and reperfusion of the left coronary artery, showing typical QT prolongation and elevation of ST segment and T wave, “Bead occlusion⁄reperfusion” is an effective procedure which can be used to study rabbit model of myocardial ischemia and infarction.

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