In vitro and In vivo Efficacy of Antifungal Agents against Acremonium sp.

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  • Duc Pham Minh
    Laboratory of Fish Diseases, Nippon Veterinary and Life Science University College of Aquaculture and Fisheries, Cantho University
  • Wada Shinpei
    Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
  • Kurata Osamu
    Laboratory of Fish Diseases, Nippon Veterinary and Life Science University
  • Hatai Kishio
    Laboratory of Fish Diseases, Nippon Veterinary and Life Science University

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Other Title
  • Acremonium sp.に対する各種抗真菌剤のin vitroおよびin vivoでの効果

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Description

Acremonium sp. NJM 0672, isolated from diseased mantis shrimp Oratosquilla oratoria, was susceptible in vitro to three kinds of antifungal agents: voriconazole, amphotericin B and terbinafine hydrochloride. Voriconazole was selected to treat kuruma prawn Penaeus japonicus, which had been intramuscularly injected with 0.1 mL of 5.0 × 104 conidia/mL of Acremonium sp. Voriconazole was administered orally at doses of 6 and 2 mg/kg body weight per day for 7 consecutive days, or intramuscularly injected at doses of 4 and 2 mg/kg body weight per day for 3 consecutive days. Both treatments were begun at 6 h after injection of the conidial suspension. The gross features, mortality and histopathological findings demonstrated that voriconazole was an efficient antifungal agent against Acremonium sp.

Journal

  • Fish Pathology

    Fish Pathology 45 (3), 109-114, 2010

    The Japanese Society of Fish Pathology

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