Studies on a new chemotherapautic agent nifurprazine (HB-115) against fishinfectious diseases -Part I

SHIRAKI Kenji, MIYAMOTO Fumio, SATO Toshihisa, SONEZAKI Iwao, YANO Kuniichro

doi:10.3147/jsfp.4.130

Some experiments were carried out to evaluate nifurprazine (HB-115) as a preventive agent for bacterial infectious diseases of fish. The results of those is as follows.<BR>1. Nifurprazine is highly active against fish pathogenic bacteria, Vibrio anguillarum, Aeromonas sp., Chondrococcus columnaris or Vibrio sp. isolated from marine organisms. It was found that the antibacterial activity of nifurprazine was twenty to three hundred times as high as nitrofurazone furazolidone, chloramphenicol or chlortetracycline. It inhibited the growth of those bacteria at the concentrations as low as 0.01 to 0.04mcg/ml.<BR>2. When eels were kept in the water containing nifurprazine at such a high level as 300 ppm for 30 minutes at 20°C, the treated eels did not show any toxic signs. <BR>3. The results of experiments in which eels that had been previously infected with Vibrio anguillarum and Aeromonas sp. were treated by medicated bathing method with nifurprazine indicated that nifurprazine was highly effective in preventing eels from those bacterial infections. The preventive effect of nifurprazine is superior to those of the well known nitrofuran derivatives.

Studies on a new chemotherapautic agent nifurprazine (HB-115) against fishinfectious diseases -Part I

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