Protective Efficacy of a Formalin-Killed Vaccine against Atypical Edwardsiella tarda Infection in Red Sea Bream Pagrus major

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  • マダイの非定型Edwardsiella tarda感染症に対する不活化ワクチンの効果

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Edwardsiella tarda causes high mortality infections in fish. To determine the efficacy of a vaccine against E. tarda, a formalin-killed preparation of atypical E. tarda FPC503 was intraperitoneally injected into red sea bream Pagrus major with or without the oil adjuvant, Montanide ISA 763 A VG. Both vaccine regimens showed protective efficacy against experimental infection with E. tarda FPC503 at 28 and 56 days post-vaccination. An enzyme-linked immunosorbent assay (ELISA) revealed the specific antibody production in vaccinated fish but the relationship between protective efficacy and antibody titer was not clear. The present results indicate that the formalin-killed vaccine is useful for the prevention of atypical E. tarda infection in red sea bream.

Journal

  • Fish Pathology

    Fish Pathology 46 (4), 120-122, 2011

    The Japanese Society of Fish Pathology

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