Alteration of cholesterol metabolism and hypocholesterolemic properties of 4-O-methylascochlorin in controlled reverse-phase feeding rats.
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- HOSOKAWA Tomoyoshi
- Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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- SAWADA Mikio
- Research Laboratories, Chugai Pharmaceutical Co., Ltd.
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- ANDO Kunio
- Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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- TAMURA Gakuzo
- Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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説明
Modified fungal product 4-O-methylascochlorin (MAC) is an experimental agent affecting lipid and carbohydrate metabolism in mammals. The hypocholesterolemic properties of MAC were studied using rats fed on a standard laboratory diet. Because of the insolubility in water, reproducibility of the hypocholesterolemic activity had usually been poor for rats fed ad libitum. The difficulty was overcome by controlled reverse-phase feeding; MAC significantly lowered serum total cholesterol (s-TC) in rats only when given by gastric intubation soon after diet intake.<br> MAC increased fecal excretion of neutral and acidic sterols and also increased biliary flow accompanying increments in biliary cholesterol, bile acids and phospholipids. A much larger increase in neutral sterols was characteristic for MAC. However, intestinal absorption of cholesterol and cholic acid was unaffected by MAC. Three mechanisms therefore seemed to be working in hypocholesterolemic activity:(a) withdrawal of hepatic cholesterol into bile, (b) a larger fecal loss of sterols following increment of biliary sterols and (c) enhanced bile acid synthesis compensating the larger fecal loss. A negative sterol balance often leads to an increase in hepatic cholesterogenesis. However, cholesterogenesis, as judged from incorporation of the precursors, was unchanged by MAC.
収録刊行物
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- Agricultural and Biological Chemistry
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Agricultural and Biological Chemistry 46 (3), 775-781, 1982
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206464702080
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- NII論文ID
- 130000028101
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- COI
- 1:CAS:528:DyaL38XhslCiu7w%3D
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- ISSN
- 18811280
- 00021369
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- 使用不可