Enhanced excretion of fecal neutral sterols and the hypocholesterolemic property of 4-O-methylascochlorin in mice.
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- HOSOKAWA Tomoyoshi
- Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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- SAWADA Mikio
- Research Laboratories, Chugai Pharmaceutical Co.
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- ANDO Kunio
- Research Laboratories, Chugai Pharmaceutical Co.
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- TAMURA Gakuzo
- Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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説明
The hypocholesterolemic property of experimental agent 4-O-methylascochlorin (MAC) was examined in male mice. MAC exerted hypocholesterolemic activity without hepatomegaly in mice given MAC mixed in a standard laboratory diet for a week. MAC also significantly reduced plasma total cholesterol (p-TC) in mice when it was administered immediately after meals by gastric intubation in controlled feeding. However, the oral administration through gastric tube was completely ineffective on p-TC in mice with empty stomach. These results suggest a close relationship between hypocholesterolemic efficacy and the timing of diet intake. Hypercholesterolemia also induced by a high fat-cholesterol diet was unaffected by MAC when it was given mixed with the diet.<br> From the isotopic study, three plausible mechanism were proposed for the mode of action: (I) enhanced output of biliary cholesterol, (II) inhibition of intestinal cholesterol absorption followed by an increment of fecal neutral sterols and (III) modulation of cholesterol partition in the plasma.
収録刊行物
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- Agricultural and Biological Chemistry
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Agricultural and Biological Chemistry 44 (10), 2461-2468, 1980
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206464836864
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- NII論文ID
- 130003416278
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- COI
- 1:CAS:528:DyaL3MXis10%3D
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- ISSN
- 18811280
- 00021369
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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