Enhanced excretion of fecal neutral sterols and the hypocholesterolemic property of 4-O-methylascochlorin in mice.

DOI DOI オープンアクセス
  • HOSOKAWA Tomoyoshi
    Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
  • SAWADA Mikio
    Research Laboratories, Chugai Pharmaceutical Co.
  • ANDO Kunio
    Research Laboratories, Chugai Pharmaceutical Co.
  • TAMURA Gakuzo
    Laboratory of Microbiology, Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo

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説明

The hypocholesterolemic property of experimental agent 4-O-methylascochlorin (MAC) was examined in male mice. MAC exerted hypocholesterolemic activity without hepatomegaly in mice given MAC mixed in a standard laboratory diet for a week. MAC also significantly reduced plasma total cholesterol (p-TC) in mice when it was administered immediately after meals by gastric intubation in controlled feeding. However, the oral administration through gastric tube was completely ineffective on p-TC in mice with empty stomach. These results suggest a close relationship between hypocholesterolemic efficacy and the timing of diet intake. Hypercholesterolemia also induced by a high fat-cholesterol diet was unaffected by MAC when it was given mixed with the diet.<br> From the isotopic study, three plausible mechanism were proposed for the mode of action: (I) enhanced output of biliary cholesterol, (II) inhibition of intestinal cholesterol absorption followed by an increment of fecal neutral sterols and (III) modulation of cholesterol partition in the plasma.

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詳細情報 詳細情報について

  • CRID
    1390001206464836864
  • NII論文ID
    130003416278
  • DOI
    10.1271/bbb1961.44.2461
    10.1080/00021369.1980.10864329
  • COI
    1:CAS:528:DyaL3MXis10%3D
  • ISSN
    18811280
    00021369
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
    • OpenAIRE
  • 抄録ライセンスフラグ
    使用不可

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