LET Effects in Micrococcus radiodurans Irradiated

DOI

書誌事項

タイトル別名
  • LET Effects in <i>Micrococcus radiodurans</i> Irradiated
  • with Alpha Particles in the Liquid Phase

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説明

From view point of the study on LET effects on bacteria, log- and stationary-phase cells of M. radiodurans, an extremely radioresistant vegetative bacterium, suspended in the phosphate buffer were exposed to 26 MeV α-particles from the IPCR cyclotron. The results obtained were compared with those on γ-irradiation. On such liquid-phase irradiation, survival curves of M. radiodurans for α-particles were found exponential while they were of sigmoidal or cumulative type for γ-rays. In addition, the dose-rate effect was observed with α-bombardment, although it was not found with γ-irradiation. For a given dose and in a system where the effective volume was sufficiently small as compared with the total sample volume, the relation of the surviving fraction S to the beam intensity I was represented by an empirical equation, S-exp[-(It/q0){1-exp(-kq0/I)p}] where t is irradiation time, q0 is D37, and k and p are constant. By means of sedimentation analysis, double-strand scissions in DNA caused by α-particles were found repairable during the postirradiation incubation similarly to the case of γ-irradiation. The findings observed here with M. radiodurans do not support the view that DNA is an only primary target for cell killing by α-particles.

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詳細情報 詳細情報について

  • CRID
    1390001206467729408
  • NII論文ID
    130003523472
  • DOI
    10.1271/bbb1961.34.1346
  • COI
    1:CAS:528:DyaE3MXitVSltA%3D%3D
  • ISSN
    18811280
    00021369
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • Crossref
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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