Chemical and pharmacological properties of vasopressor phospholipid in crude soybean lecithin.
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- TOKUMURA Akira
- Faculty of Pharmaceutical Sciences, Tokushima University
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- AKAMATSU Yasue
- Faculty of Pharmaceutical Sciences, Tokushima University
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- YAMADA Sadaji
- Faculty of Pharmaceutical Sciences, Tokushima University
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- TSUKATANI Hiroaki
- Faculty of Pharmaceutical Sciences, Tokushima University
説明
Commercial soybean lecithin has a potent hypertensive effect on anesthetized rats. Crude soybean lecithin was separated into two fractions with respect to solubility in cold acetone. The acetone-insoluble fraction containing most pressor activity was separated into two further active fractions by column chromatography on silicic acid. The active fraction eluted with chloroform-methanol mixture (4:6) was further purified by gel filtration on Sephadex LH-20. The purified pressor substance had phosphorus and was labile to alkali. Its chromatographic and partition behaviors indicate that it may be a polar acidic phospholipid. The short-lasting pressor response produced by the active lipid was not reduced by mechanical injury to the central nervous system or treatment with an a-adrenergic blocking agent or a ganglion-blocking agent.
収録刊行物
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- Agricultural and Biological Chemistry
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Agricultural and Biological Chemistry 42 (3), 515-521, 1978
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206468419840
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- NII論文ID
- 130003525976
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- COI
- 1:CAS:528:DyaE1cXhvVynsb0%3D
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- ISSN
- 18811280
- 00021369
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可