Chemical and pharmacological properties of vasopressor phospholipid in crude soybean lecithin.

DOI

Abstract

Commercial soybean lecithin has a potent hypertensive effect on anesthetized rats. Crude soybean lecithin was separated into two fractions with respect to solubility in cold acetone. The acetone-insoluble fraction containing most pressor activity was separated into two further active fractions by column chromatography on silicic acid. The active fraction eluted with chloroform-methanol mixture (4:6) was further purified by gel filtration on Sephadex LH-20. The purified pressor substance had phosphorus and was labile to alkali. Its chromatographic and partition behaviors indicate that it may be a polar acidic phospholipid. The short-lasting pressor response produced by the active lipid was not reduced by mechanical injury to the central nervous system or treatment with an a-adrenergic blocking agent or a ganglion-blocking agent.

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Details 詳細情報について

  • CRID
    1390001206468419840
  • NII Article ID
    130003525976
  • DOI
    10.1271/bbb1961.42.515
  • COI
    1:CAS:528:DyaE1cXhvVynsb0%3D
  • ISSN
    18811280
    00021369
  • Text Lang
    en
  • Data Source
    • JaLC
    • Crossref
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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