Determination of optical isomers of fenvalerate (S-5602) as their l-menthyl ester derivatives by high performance liquid chromatography.

HORIBA Masao, KITAHARA Hajimu, YAMAMOTO Seiya, MURANO Atsushi

doi:10.1080/00021369.1980.10864109

Determination of optical isomers of fenvalerate (S-5602) as their l-menthyl ester derivatives by high performance liquid chromatography.

DOI DOI オープンアクセス

HORIBA Masao

Institute for Biological Science, Sumitomo Chemical Co., Ltd.
KITAHARA Hajimu

Institute for Biological Science, Sumitomo Chemical Co., Ltd.
YAMAMOTO Seiya

Institute for Biological Science, Sumitomo Chemical Co., Ltd.
MURANO Atsushi

Ohita Works, Sumitomo Chemical Co., Ltd.

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説明

An analytical method was developed for determining the four optical isomers of a new synthetic pyrethroidal insecticide, α-cyano-3-phenoxy-benzyl 2-(4-chlorophenyl)isovalerate (Fenvalerate, S-5602). The cyano group in S-5602 molecule was converted into l-menthyloxy-carbonyl group by heating S-5602 with l-menthol and hydrochloric acid. The obtained diastereoisomer derivative (l-menthyl ester deriv.) was chromatographed on a μPorasil column (4mm i.d.×0.3m) using a solvent system of hexane-ethyl acetate (500+7, v/v) as a mobile phase, and the four isomers of S-5602 were separated from one another within 20min. The compositions of S-5602 isomers were determined from their peak areas.