Feeding of Vitamin B12 Rapidly Increases the Specific Activity of Hepatic Methyl-malonyl-CoA Mutase in Vitamin B12-Deficient Rats.

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  • Feeding of Vitamin B<sub>12</sub>Rapidly Increases the Specific Activity of Hepatic Methyl-malonyl-CoA Mutase in Vitamin B<sub>12</sub>-Deficient Rats

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Vitamin B12-deticient rats were used to study the effects of feeding vitamin B12 on hepatic methylmalonyl-CoA mutase activity, which was decreased by the deficiency. A significant and rapid increase in the specitic activity of the enzyme was caused by feeding vitamin B 12, suggesting that the rate of synthesis of the enzyme protein is accelerated by the feeding.

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