Microbial Production of Glycyrrhetic Acid 3-<i>O</i>-Mono-<i>β</i>-D-Glucuronide from Glycyrrhizin by<i>Cryptococcus magnus</i>MG-27

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  • Microbial Production of Glycyrrhetic Acid 3-O-Mono-.BETA.-D-Glucuronide from Glycyrrhizin by Cryptococcus magnus MG-27.

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It was found that Cryptococcus magnus MG-27, a yeast isolated from soil, selectively hydrolyzed the terminal β-glucuronyl linkage of glycyrrhizin (1) to yield glycyrrhetic acid 3-O-mono-β-D-glucuronide (MGGR, 3), a potent sweetener (relative sweetness to sucrose : x941). The conditions for cultivation of this yeast with the maximum hydrolytic activity as well as the reaction conditions of 1 with the cells for the maximum yield of 3 were investigated. Based on the results, strain MG-27 was cultivated with a medium composed of 1.0% 1, 1.0% glucose, 0.5% Polypepton, and 0.3% yeast extract at 28 °C for 24h. The reaction of the resulting cells and 1 at pH 5.7 at 45 °C for 48h afforded 3 in a yield of 95%.

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