Large-scale Preparation of (<i>R</i>)-(–)-1,3-Butanediol from the Racemate by<i>Candida parapsilosis</i>

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  • Large-scale Preparation of (R)-(-)-1,3-Butanediol from the Racemate by Candida parapsilosis.

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Large-scale preparation of (R)-(-)-1, 3-butanediol (R-BDO), an important chiral synthon, from the racemate by Candida parapsilosis IFO 1396 was investigated. We found that ethanol accumulated during culture enhanced the secondary alcohol oxido-reduction activity of cells. Large-scale preparation of R-BDO was done using a fermentor. 3092g of R-BDO was obtained from the racemate by the use of this strain with 94. 0°C enantiomeric excess.

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