Inhibition of Tumor Cell Growth by A Specific 6-Phosphofructo-2-kinase Inhibitor,<i>N</i>-Bromoacetylethanolamine Phosphate, and Its Analogues
-
- HIRATA Takafumi
- Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, Nagasaki University
-
- WATANABE Mitsuaki
- Center for Instrumental Analysis, Nagasaki University
-
- MIURA Shinji
- Biology Laboratory, Biochemicals Division, Yamasa Corporation
-
- IJICHI Katsushi
- Biology Laboratory, Biochemicals Division, Yamasa Corporation
-
- FUKASAWA Masashi
- Department of Microbiology, National Defense Medical College
-
- SAKAKIBARA Ryuzo
- Department of Home Economics, Nutrition and Food Science Course, Kyushu Women’s University
書誌事項
- タイトル別名
-
- Inhibition of Tumor Cell Growth by A Specific 6-Phosphofructo-2-kinase Inhibitor, N-Bromoacetylethanolamine Phosphate, and Its Analogues.
この論文をさがす
抄録
The high rate of glycolysis despite the presence of oxygen and mitochondria in tumor cells implies an important role for this process in cell division. The rate of glycolysis is assumed to be dependent on the cellular concentration of fructose 2,6-bisphosphate, the concentration of which in turn depends on a bifunctional enzyme and the ratio of this enzyme’s 6-phosphofructo-2-kinase versus its fructose 2,6-bisphosphatase activities. To prove the hypothesis that inhibition of glycolysis in tumor cells by 6-phosphofructo-2-kinase inhibitors would cause inhibition of tumor cell proliferation, ten N-bromoacetylethanolamine phosphate analogues were designed, synthesized, and tested. They were screened for their activities against various human tumor cell lines to study the effects of inhibition of glycolysis on cell proliferation. The relationship between the structure of these compounds and their inhibitory activity on cell proliferation was also discussed. It was found that the activity of N-(2-methoxyethyl)-bromoacetamide, N-(2-ethoxyethyl)-bromoacetamide, and N-(3-methoxypropyl)-bromoacetamide was comparable to that of the positive control AraC. These three inhibitors showed in vivo anticancer effects in P388 transplant BDF1 mice.<br>
収録刊行物
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 64 (10), 2047-2052, 2000
公益社団法人 日本農芸化学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001206472896128
-
- NII論文ID
- 110002679775
-
- NII書誌ID
- AA10824164
-
- COI
- 1:CAS:528:DC%2BD3cXnvVOhtrY%3D
-
- ISSN
- 13476947
- 09168451
-
- NDL書誌ID
- 5557581
-
- PubMed
- 11129574
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- 抄録ライセンスフラグ
- 使用不可