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- FUNADA Ulala
- Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- WADA Masahiro
- Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- KAWATA Tetsunori
- Faculty of Education, Okayama University
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- TANAKA Nobuo
- Seifuso Hospital
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- TADOKORO Tadahiro
- Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
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- MAEKAWA Akio
- Department of Applied Biology and Chemistry, Faculty of Applied Bioscience, Tokyo University of Agriculture
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抄録
Cyanocobalamin, deoxyadenosylcobalamin and methylcobalamin were separately administered to mice sensitized with the ovalbumin antigen to investigate the allergic response. The serum IgE and pulmonary histamine concentrations were significantly lower in all cobalamin (Cbl)-administered groups. The production of interleukin (IL)-2 and IL-4 in splenocytes was also lower in all Cbl-administered groups. These results show that Cbls were effective in mitigating allergic reactions and IL-2 production. CD3+CD28+ (CD28 is an accessory molecule related to IL-2 production) and CD4+CD28+ in splenocytes were higher in all the Cbl-administered groups. However, CD3+CD28-, CD4+CD28- and CD5+CD25- (CD25: IL-2 Rα/p55) were lower in the Cbl-administered groups. In addition, Cbl specifically inhibited the cellular phosphorylation of tyrosine induced by ovalbumin sensitization. These results indicate that the signal in a cell by CD 28 was restrained by Cbl. We infer that Cbl administration significantly reduced the IL-2 concentration, and secondarily the IL-4, IgE and histamine concentrations.<br>
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 64 (10), 2053-2058, 2000
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206472900352
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- NII論文ID
- 110002679776
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3cXnvVOhtrc%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 5557594
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- PubMed
- 11129575
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可