Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosisbu the Inhibition of Oxidative Respiration
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- ASHIKAGA Takao
- Department of Bioengineering, Tokyo Institute of Technology
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- HONMA Mariko
- Department of Pharmaceutical Science, Kyoritsu College of Pharmacy
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- MUNEMURA Kazuko
- Department of Agricultural Chemistry, the University of Tokyo
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- KATAOKA Takao
- Department of Bioengineering, Tokyo Institute of Technology
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- ENDO Toyoshige
- Department of Pharmaceutical Science, Kyoritsu College of Pharmacy
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- YAMASAKI Makari
- Department of Agricultural Chemistry, the University of Tokyo
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- MAGAE Junji
- Department of Bioengineering, Tokyo Institute of Technology
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- NAGAI Kazuo
- Department of Bioengineering, Tokyo Institute of Technology
書誌事項
- タイトル別名
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- Selective Induction of Interleukin-1 Production and Tumor Killing Activity of Macrophages Through Apoptosis by the Inhibition of Oxidative Respiration.
- Selective Induction of Interleukin-1 Pr
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説明
Suppression of mitochondrial respiration and increased glycolysis are characteristic features of activated macrophages. We show here that antimycin A, a respiratory inhibitor, induced interleukin-1 synthesis and tumoricidal activity without inducing tumor necrosis factor or nitric oxide. The induction of tumoricidal activity was resistant to inhibitors of tyrosine-specific protein kinases and intracellular glycoprotein transport. The cognate interaction between macrophages and target cells was not a prerequisite for the tumoricidal activity. In contrast, lipopolysaccharide induced the production of interleukin-1, tumor necrosis factor and nitric oxide, the induction of tumoricidal activity being sensitive to genistein and brefeldin A. Antimycin A, like lipopolysaccharide, induced the release of a cytoplasmic enzyme and apoptosis of macrophages. Antimycin A showed anti-metastatic activity in vivo. These results suggest that the inhibition of oxidative respiration would induce apoptosis and the resultant release of soluble effector molecules of macrophages which inhibit tumor metastasis in vivo.<br>
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 62 (6), 1115-1121, 1998
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206473448704
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- NII論文ID
- 110002679220
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DyaK1cXksFCju7s%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 4514501
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- PubMed
- 9692192
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- 使用不可