Inhibition of Telomerase Activity by Fungus Metabolites, CRM646-A and Thielavin B.

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  • TOGASHI Ken-ichi
    Antibiotics Laboratory, RIKEN Present address: Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo
  • KO Hack-Ryong
    Antibiotics Laboratory, RIKEN Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology
  • AHN Jong-Seog
    Cellular Response Modifier Research Unit, Korea Research Institute of Bioscience and Biotechnology
  • OSADA Hiroyuki
    Antibiotics Laboratory, RIKEN

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Abstract

We performed a screening program to identify telomerase inhibitors from our drug source obtained from fungus fermentations, and found that two compounds, CRM646-A and thielavin B, inhibited telomerase activity at doses of 3.2 and 32 μM, respectively. These compounds also inhibited the activity of viral reverse transcriptase at almost the same dose levels which inhibited telomerase activity.

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