Elevation of Intracellular cAMP Levels by Dominant Active Heterotrimeric G Protein Alpha Subunits ScGP-A and ScCP-C in Homobasidiomycete, Schizophyllum commune
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- YAMAGISHI Kenji
- National Agricultural Research Center for the Tohoku Region, National Agricultural Research Organization
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- KIMURA Toshiyuki
- National Agricultural Research Center for the Tohoku Region, National Agricultural Research Organization
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- SUZUKI Masahiro
- National Agricultural Research Center for the Tohoku Region, National Agricultural Research Organization
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- SHINMOTO Hiroshi
- National Food Research Institute
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- YAMAKI Ko-ji
- National Agricultural Research Center for the Tohoku Region, National Agricultural Research Organization
書誌事項
- タイトル別名
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- Elevation of Intracellular cAMP Levels by Dominant Active Heterotrimeric G Protein Alpha Subunits ScGP-A and ScGP-C in Homobasidiomycete, Schizophyllum commune
- Elevation of Intracellular cAMP Levels by Dominant Active Heterotrimeric G Protein Alpha Subunits<i>ScGP-A</i>and<i>ScGP-C</i>in Homobasidiomycete,<i>Schizophyllum commune</i>
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抄録
In many fungi, the heterotrimeric G protein alpha subunits, and/or small G protein (RAS) control intracellular cAMP levels. But it is not clear which types of G proteins modulate cAMP levels in homobasidiomycete (mushrooms). To explain the mechanism, we expressed dominant active RAS (a homolog of S. cerevisiae RAS1) in homobasidiomycete Schizophyllum commune and compared the cAMP levels in the transformed clones with those of clones expressing dominant active heterotrimeric G protein alpha subunits ScGP-A, B, and C. The results demonstrated that the dominant active ScGP-A and C elevated the intracellular cAMP levels. In contrast, the dominant active S. commune RAS gene did not affect the cAMP levels, even though colony growth and formation of fruiting bodies were apparently repressed. These data suggest that the heterotrimeric G protein alpha subunits are involved in the mechanism of cAMP regulation, and that RAS modulates another signal-transduction pathway regulating cell growth and differentiation.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 68 (5), 1017-1026, 2004
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206473893888
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- NII論文ID
- 10013144460
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 6957380
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- PubMed
- 15170104
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可