Involvement of a Glu71-Arg64 Couple in the Access Channel for NADH in Cytochrome P450nor

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  • SU Fei
    Institute of Applied Biochemistry, University of Tsukuba
  • FUSHINOBU Shinya
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo
  • TAKAYA Naoki
    Institute of Applied Biochemistry, University of Tsukuba
  • SHOUN Hirofumi
    Department of Biotechnology, Graduate School of Agricultural and Life Sciences, The University of Tokyo

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Description

Putative access channel for NADH in the heme-distal pocket of cytochrome P450nor (P450nor) comprises many charged amino acid residues. Characterization of the E71A mutant protein of P450nor highlights the existence of a unique mechanism for binding NADH that depends on the salt bridge network between Glu71, Arg64 and Asp88.

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