Effect of Dietary Linoleate/alpha-Linolenate Balance on the Brain Lipid Composition, Reproductive Outcome Behavior of Rats during Their Prenatal and Postnatal Development

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  • CHEON Sang-Hee
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.
  • HUH Moon-Haeng
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.
  • LEE Yoon-Bok
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.
  • PARK Jeom-Seon
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.
  • SOHN Heon-Soo
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.
  • CHUNG Chai-Won
    Department of Laboratory Animal Science, Central Research Institute, Dr. Chung's Food Co. Ltd.

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  • Effect of Dietary Linoleate/alpha-Linolenate Balance on the Brain Lipid Composition, Reproductive Octcome and Behavior of Rats during Their Prenatal and Postnatal Development.
  • Effect of Dietary Linoleate/alpha-Linolenate Balance on the Brain Lipid Composition, Reproductive Outcome and Behavior of Rats during Their Prenatal and Postnatal Development

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  The effect of the dietary linoleate (LA)/alpha-linolenate (LNA) balance during development on the brain lipid composition, reproductive outcome and behavior of rats was studied. Female rats were fed on experimental diets during pregnancy and the resulting pups for 16 weeks. The dietary LA/LNA ratios were 1.07 (LA1), 2.64 (LA2), 4.45 (LA3), 7.68 (LA4) and 10.35 (LA5). The relative content of docosahexaenoate (DHA) in the brain of pups tended to increase with decreasing LA/LNA ratio at 0 and 3 weeks, while the level of DHA was maintained constant at 16 weeks regardless of the dietary LA/LNA ratio. The learning ability was measured at 12 weeks of age, and there was no difference among the groups. In an open field test, the exploratory index was significantly lower in the LA1 group than in the LA2 group. The LA1 group had a smaller litter size and lower survival rate than the other groups. We conclude that if the diet contained appropriate amounts and balance of LA and LNA, it was possible for rats to synthesize an appropriate amount of DHA and have normal behavioral activity without DHA supplementation.<br>

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