Induction of Nitric Oxide Synthase by Saponins of Heat-Processed Ginseng
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- KIM Ji Yeon
- College of Pharmacy, Sookmyung Women’s University
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- LEE Hwa Jin
- College of Pharmacy, Sookmyung Women’s University
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- KIM Ji Sun
- College of Pharmacy, Sookmyung Women’s University
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- RYU Jae-Ha
- College of Pharmacy, Sookmyung Women’s University
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Abstract
Total saponin of heat-processed ginseng (TSHG) stimulated the production of nitric oxide (NO) in interferon-γ (IFN-γ)-primed macrophages through the increased expression of inducible nitric oxide synthase (iNOS). However, TSHG by itself had a very weak effect on the NO synthesis without IFN-γ priming. The saponins of white ginseng inhibited the NO production in lipopolysaccharide (LPS)/IFN-γ activated macrophages rather than the stimulation of NO production found in IFN-γ primed macrophages. The NO production by TSHG-stimulated macrophages was inhibited by the NOS inhibitor (NG-monomethyl-L-arginine (L-NMMA)) and nuclear factor-kappaB inhibitor (pyrrolidine dithiocarbamate (PDTC)). TSHG showed different serum-dependence from LPS on the activation of IFN-γ primed macrophages. This property of TSHG may explain the intensified anti-tumor properties of heat-processed ginseng through its immunostimulating activity.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (5), 891-895, 2005
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206474794624
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- NII Article ID
- 130000030317
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7322345
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- PubMed
- 15914906
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed