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Effects of the Cell Wall of Kluyveromyces marxianus YIT 8292 on the Plasma Cholesterol and Fecal Sterol Excretion in Rats Fed on a High-Cholesterol Diet
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- YOSHIDA Yasuto
- Yakult Central Institute for Microbiological Research
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- YOKOI Wakae
- Yakult Central Institute for Microbiological Research
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- OHISHI Kenji
- Yakult Central Institute for Microbiological Research
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- ITO Masahiko
- Yakult Central Institute for Microbiological Research
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- NAITO Eiichiro
- Yakult Central Institute for Microbiological Research
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- SAWADA Haruji
- Yakult Central Institute for Microbiological Research
Bibliographic Information
- Other Title
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- Effects of the Cell Wall of<i>Kluyveromyces marxianus</i>YIT 8292 on the Plasma Cholesterol and Fecal Sterol Excretion in Rats Fed on a High-Cholesterol Diet
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Description
The cellular components involved in the hypocholesterolemic activity of Kluyveromyces marxianus YIT 8292 were examined in rats fed on a high-cholesterol diet. Whole cells (KM) were heated at 115 °C for 10 minutes and fractionated into water-soluble extract 1 and the insoluble residue (KM-CW). After mechanical disruption by glass beads, KM-CW was separated into the cell wall (KM-W) and water-soluble extract 2. Plasma total cholesterol was decreased by feeding KM-CW or KM-W, but was not changed by feeding extract 1 or extract 2. Feeding KM-CW and KM-W increased the fecal sterol excretion and concentration of short-chain fatty acids (SCFA) in the cecum. The hypocholesterolemic activity of KM-CW was completely abolished by the enzymatic degradation of α-mannan and β-glucan. These results suggest that α-mannan and β-glucan were the major active components of KM, and that its hypocholesterolemic activity may be attributable to the increasing fecal sterol excretion and/or production of SCFA.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 69 (4), 714-723, 2005
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206475279104
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- NII Article ID
- 130000030352
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7308280
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- PubMed
- 15849409
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed