Fosmidomycin Resistance in Adenylate Cyclase Deficient (cya) Mutants of Escherichia coli

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  • SAKAMOTO Yoshiko
    <i>Department of Food Science and Technology, College of Bioresouce Sciences, Nihon University</i>
  • FURUKAWA Soichi
    <i>Department of Food Science and Technology, College of Bioresouce Sciences, Nihon University</i>
  • OGIHARA Hirokazu
    <i>Department of Food Science and Technology, College of Bioresouce Sciences, Nihon University</i>
  • YAMASAKI Makari
    <i>Department of Food Science and Technology, College of Bioresouce Sciences, Nihon University</i>

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  • Fosmidomycin Resistance in Adenylate Cyclase Deficient (<i>cya</i>) Mutants of<i>Escherichia coli</i>

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Adenylate cyclase deficient (cya) mutants of E. coli K-12 were found to be resistant to fosmidomycin, a specific inhibitor of the non-mevalonate pathway, just like to fosfomycin. E. coli glpT mutants were resistant to fosfomycin and also to fosmidomycin. This fact shows that fosmidomycin was transported inside via the glycerol-3-phosphate transporter, GlpT. DNA micro-array analysis showed that the transcription of glpT and other genes concerning glycerol utilization were highly dependent on the presence of cAMP.<br>

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