Functional Analysis of the Promoter of the Saccharomyces cerevisiae Multidrug Resistance Gene YDR1, which Encodes a Member of the ATP Binding Cassette (ABC) Superfamily.

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  • Functional Analysis of the Promoter of the<i>Saccharomyces cerevisiae</i>Multidrug Resistance Gene<i>YDR1</i>, which Encodes a Member of the ATP Binding Cassette (ABC) Superfamily

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The Saccharomyces cerevisiae gene YDR1/PDR5/STS1, which encodes a member of the ATP binding cassette (ABC) superfamily, is important for cross-resistance to apparently unrelated drugs. The expression of YDR1 is induced by various drugs and heat shock [Hirata et al., Curr. Genet., 26, 285-294 (1994)]. By deletion analysis of the 5'-noncoding region of the YDR1 gene, two drug responsive regions (-604 to -485 and -335 to -275) were identified with fluphenazine and cycloheximide. Three conserved palindrome sequences were found in these regions.

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