Determination of Endogenous Peptides with in Vitro ACE Inhibitory Activity in Normotensive Human Plasma by the Fluorometric HPLC Method.

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  • Determination of Endogenous Peptides wi
  • Determination of Endogenous Peptides with<i>in Vitro</i>ACE Inhibitory Activity in Normotensive Human Plasma by the Fluorometric HPLC Method

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An in vitro degradation test of angiotensin (ANG) II or III in normotensive supine human plasma from 9 healthy male subjects confirmed the production of smaller ANG metabolites with angio-tensin I-converting enzyme inhibitory activity. These metabolites were identified as ANG (3-8), ANG (4-8), ANG (5-8), and ANG (3-4), whose respective peptide concentrations were determined by our proposed naphthalene-2, 3-dialdehyde (NDA)-HPLC method to be 64±9, 39±5, 176±22, and 197±35 fmol/ml of plasma.

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