Determination of Endogenous Peptides with in Vitro ACE Inhibitory Activity in Normotensive Human Plasma by the Fluorometric HPLC Method.

Bibliographic Information

Other Title
  • Determination of Endogenous Peptides wi
  • Determination of Endogenous Peptides with<i>in Vitro</i>ACE Inhibitory Activity in Normotensive Human Plasma by the Fluorometric HPLC Method

Search this article

Description

An in vitro degradation test of angiotensin (ANG) II or III in normotensive supine human plasma from 9 healthy male subjects confirmed the production of smaller ANG metabolites with angio-tensin I-converting enzyme inhibitory activity. These metabolites were identified as ANG (3-8), ANG (4-8), ANG (5-8), and ANG (3-4), whose respective peptide concentrations were determined by our proposed naphthalene-2, 3-dialdehyde (NDA)-HPLC method to be 64±9, 39±5, 176±22, and 197±35 fmol/ml of plasma.

Journal

Citations (4)*help

See more

References(15)*help

See more

Details 詳細情報について

Report a problem

Back to top