Microbial Resolution of 2-Hydloxy-3-nitropropionic Acid for Synthesis of Optically Active Isoserine
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- YASOHARA Yoshihiko
- Fine Chemicals Research Laboratories, Kaneka Corporation
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- HASEGAWA Junzo
- Fine Chemicals Research Laboratories, Kaneka Corporation
書誌事項
- タイトル別名
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- Microbial Resolution of 2-Hydroxy-3-nitropropionic Acid for Synthesis of Optically Active Isoserine.
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抄録
The biocatalytic stereoselective hydrolysis of 2-hydroxy-3-nitropropionic acid esters was studied. Forty enzymes and three hundred microorganism strains were examined for their ability to hydrolyze ethyl 2-hydroxy-3-nitropropionic acid. Nocardia globerula IFO13150 gave n-butyl (R)-2-hydroxy-3-nitropropionate with a 92% enantiomeric excess (ee) and the corresponding carboxylic acid with a 92%ee, which was easily converted to (S)-isoserine, a useful β-amino acid.
収録刊行物
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- Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ
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Ｂｉｏｓｃｉｅｎｃｅ， Ｂｉｏｔｅｃｈｎｏｌｏｇｙ， ａｎｄ Ｂｉｏｃｈｅｍｉｓｔｒｙ 65 (5), 1258-1260, 2001
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206476120576
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- NII論文ID
- 110002680430
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- NII書誌ID
- AA10824164
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- COI
- 1:CAS:528:DC%2BD3MXktFait70%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 5783063
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- PubMed
- 11440154
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可