Effect of .BETA.-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
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- KAWAHARA Takeshi
- Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
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- KATAYAMA Daisuke
- Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
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- OTANI Hajime
- Integrated Department of Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University
Bibliographic Information
- Other Title
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- Effect of β-Casein (1-28) on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
- Effect of ベータ Casein 1 28 on Proliferative Responses and Secretory Functions of Human Immunocompetent Cell Lines
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Abstract
The effect of bovine β-casein (1-28) purified from commercial casein phosphopeptide preparations on human T, B, and monocyte cell lines was evaluated. Beta-casein (1-28) enhanced the proliferation of the following: T cell lines HUT-78, Jurkat Clone E6-1, and MOLT-4; B cell lines BALL, KHM-1B, and U266B1; and monocyte cell lines U937 and HL-60. Moreover, β-casein (1-28) stimulated IgA production by KHM-1B over 96 h of culture. Semiquantitative reverse transcriptional-polymerase chain reaction analysis indicated that β-casein (1-28) enhanced mRNA expression of interleukin (IL)-6 in U266B1 and KHM-1B. These results suggest that β-casein (1-28) exerts a mitogenic effect on human T, B, and monocyte cells, and an IgA-enhancing effect on B cells.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 68 (10), 2091-2095, 2004
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206476279680
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- NII Article ID
- 130000030949
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 7130872
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- PubMed
- 15502354
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed