The aqueous solubility and thermal stability of α-lipoic acid are enhanced by cyclodextrin
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- TAKAHASHI Hideki
- Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
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- BUNGO Yuri
- Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
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- MIKUNI Katsuhiko
- Carbohydrate Research Laboratory, Ensuiko Sugar Refining Co., Ltd.
書誌事項
- タイトル別名
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- The Aqueous Solubility and Thermal Stability of .ALPHA.-Lipoic Acid Are Enhanced by Cyclodextrin
- The aqueous solubility and thermal stability of a lipoic acid are enhanced by cyclodextrin
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We investigated the effects of various cyclodextrins (CDs) on the aqueous solubility and thermal stability of α-lipoic acid, a compound with low water solubility. α-CD, β-CD, and γ-CD had little effect on the aqueous solubility of α-lipoic acid. In contrast, 6-O-α-maltosyl-CDs increased it in a concentration-dependent manner, 6-O-α-maltosyl-β-CD enhancing solubility the most. The thermal stability of α-lipoic acid in the solid state was improved by the addition of G2-β-CD®, a commercial product of 6-O-α-maltosyl-β-CD. The thermal stability of α-lipoic acid was also improved by the addition of β-CD. Analysis by differential scanning calorimetry showed that G2-β-CD®, a mixture of maltosyl-β-CDs, and β-CD efficiently formed complexes with α-lipoic acid. These results suggest that the sizes and shapes of these β-CD compounds are compatible with complexation with α-lipoic acid. Moreover, both the formation of an aqueous complex with G2-β-CD® and an insoluble complex with β-CD increased the thermal stability of α-lipoic acid.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (4), 633-637, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206476931328
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- NII論文ID
- 10028271184
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- NII書誌ID
- AA10824164
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- COI
- 1:STN:280:DC%2BC3MvpvFWjsw%3D%3D
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- ISSN
- 13476947
- 09168451
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- NDL書誌ID
- 11070891
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- PubMed
- 21512253
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可