Protective Effect of Fucoxanthin against UVB-Induced Skin Photoaging in Hairless Mice
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- URIKURA Itaru
- Graduate School of Agriculture, Kyoto University
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- SUGAWARA Tatsuya
- Graduate School of Agriculture, Kyoto University
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- HIRATA Takashi
- Graduate School of Agriculture, Kyoto University
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抄録
Fucoxanthin, a major carotenoid in brown algae, has various beneficial effects. In this study, we evaluated the effect of topical fucoxanthin on UVB-induced skin photoaging in hairless mice. The dorsal skins were treated topically with a 0.001% fucoxanthin solution 2 h each time before UVB irradiation (5 times a week) for 10 weeks. The formation of wrinkles in UVB-irradiated skin treated with vehicle alone significantly increased, as compared with the non-irradiated control. Treatment with fucoxanthin tended to suppress UVB-induced wrinkle formation, but there was no significant difference between wrinkle formation in the control group and the fucoxanthin treatment group. However, topical treatment with fucoxanthin significantly lessened UVB-induced epidermal hypertrophy, VEGF, and MMP-13 expression in the epidermis and thiobarbituric acid reactive substances (TBARS) in the skin. These results indicate that topical treatment with fucoxanthin prevents skin photoaging in UVB-irradiated hairless mice, possibly via antioxidant and antiangiogenic effects.
収録刊行物
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (4), 757-760, 2011
公益社団法人 日本農芸化学会
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詳細情報 詳細情報について
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- CRID
- 1390001206476937728
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- NII論文ID
- 10028271823
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- NII書誌ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- HANDLE
- 2433/156504
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- NDL書誌ID
- 11071102
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- NDL
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