Interleukin-22 Protects against Acute Alcohol-Induced Hepatotoxicity in Mice
-
- XING Wei-Wei
- Beijing Institute of Basic Medical Sciences
-
- ZOU Min-Ji
- Beijing Institute of Basic Medical Sciences
-
- LIU Shen
- Beijing Institute of Basic Medical Sciences
-
- XU Tao
- Beijing Institute of Basic Medical Sciences
-
- WANG Jia-Xi
- Beijing Institute of Basic Medical Sciences
-
- XU Dong-Gang
- Beijing Institute of Basic Medical Sciences
Search this article
Abstract
The protective effects of interleukin-22 (IL-22) on acute alcohol-induced liver injury were investigated. Mice were gavaged with 7 doses of alcohol (56% wt/vol, 15.2 mL/kg of body weight for each dose) over the 24 h, and IL-22 (0.5 mg/kg BW) was given to the mice by injection into the tail vein 1 h after alcohol administration. The results indicated that acute alcohol administration caused prominent hepatic microvesicular steatosis and an elevation of serum transaminase activities, induced a significant decrease in hepatic glutathione in conjunction with enhanced lipid peroxidation, and increased hepatocyte apoptosis as well as hepatic TNF-alpha production. IL-22 treatment attenuated these adverse changes induced by acute alcohol administration. The protective effects of IL-22 on alcohol-induced hepatotoxicity were due mainly to its anti-inflammatory, anti-oxidant, and anti-apoptotic features.
Journal
-
- Bioscience, Biotechnology, and Biochemistry
-
Bioscience, Biotechnology, and Biochemistry 75 (7), 1290-1294, 2011
Japan Society for Bioscience, Biotechnology, and Agrochemistry
- Tweet
Details 詳細情報について
-
- CRID
- 1390001206476941952
-
- NII Article ID
- 10029329085
-
- NII Book ID
- AA10824164
-
- ISSN
- 13476947
- 09168451
-
- NDL BIB ID
- 11174248
-
- PubMed
- 21737938
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
-
- Abstract License Flag
- Disallowed