Fish Oil Feeding Up-Regulates the Expression of 5-Aminolevulinate Synthase 2 mRNA in Rat Brain
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- HARAGUCHI Tomoaki
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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- YANAKA Noriyuki
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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- EGUCHI Yuko
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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- KUDO Takahiro
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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- HIRATA Atsuko
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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- KATO Norihisa
- Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
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Description
In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.
Journal
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- Bioscience, Biotechnology, and Biochemistry
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Bioscience, Biotechnology, and Biochemistry 75 (7), 1383-1385, 2011
Japan Society for Bioscience, Biotechnology, and Agrochemistry
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Details 詳細情報について
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- CRID
- 1390001206476980096
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- NII Article ID
- 10029329549
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- NII Book ID
- AA10824164
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- ISSN
- 13476947
- 09168451
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- NDL BIB ID
- 11175240
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- PubMed
- 21737922
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- PubMed
- CiNii Articles
- OpenAIRE
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- Abstract License Flag
- Disallowed