Fish Oil Feeding Up-Regulates the Expression of 5-Aminolevulinate Synthase 2 mRNA in Rat Brain

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  • HARAGUCHI Tomoaki
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
  • YANAKA Noriyuki
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
  • EGUCHI Yuko
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
  • KUDO Takahiro
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
  • HIRATA Atsuko
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University
  • KATO Norihisa
    Department of Molecular and Applied Bioscience, Graduate School of Biosphere Science, Hiroshima University

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In this study, we investigated the effect of fish oil on gene expression in the cerebral cortex, and found that 5-aminolevulinate synthase 2 (ALAS2) mRNA expression was up-regulated by fish oil feeding. ALAS2 promoter activity was found to be regulated by retinoic acid. Our results suggest that fish oil modulates neuronal functions via heme synthesis.

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