Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-<i>p</i>-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (−)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats

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  • FUKUDA Itsuko
    Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University
  • TSUTSUI Miki
    Division of Applied Chemistry in Bioscience, Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University
  • SAKANE Iwao
    Central Research Institute, Ito En Ltd.
  • ASHIDA Hitoshi
    Research Center for Food Safety and Security, Graduate School of Agricultural Science, Kobe University Division of Applied Chemistry in Bioscience, Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University

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  • Suppression of Cytochrome P450 1A1 Expression Induced by 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mouse Hepatoma Hepa-1c1c7 Cells Treated with Serum of (-)-Epigallocatechin-3-gallate- and Green Tea Extract-Administered Rats

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The suppression of cytochrome P450 1A1 (CYP1A1) expression was examined in mouse hepatoma Hepa-1c1c7 cells treated with serum prepared from (−)-epigallocatechin-3-gallate- and green tea extract-administered rats. Catechins were found in the rat plasma after the administration. In Hepa-1c1c7 cells, 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced CYP1A1 expression was suppressed by treatment with the rat serum. It is concluded that catechins can possibly modulate CYP1A1 expression.

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